Details

Autor(en) / Beteiligte

• TOKUMARU, Takahiko
• SAKAMOTO, Junichi
• WATANABE, Tadashi
• YAMAUCHI, Nasaji
• ITO, Katsuki
• ICHIHASHI, Hidehito
• NAKAZATO, Hiroaki
• TAKAGI, Hiroshi

Titel

IMMUNOHISTOLOGICAL STUDY OF BLOOD GROUP ANTIGENS (Lea, Leb, X, Y) AND CA19-9 (SIALYLATED-Lea) IN GASTRIC CANCERS AND NORMAL GASTRIC TISSUES

Ist Teil von

• Nippon Shokakibyo Gakkai Zasshi, 1987, Vol.84(11), pp.2494-2503

Ort / Verlag

Japan: The Japanese Society of Gastroenterology

Erscheinungsjahr

1987

Quelle

MEDLINE

Beschreibungen/Notizen

• The expression of blood group antigens and blood group related cancer-associated antigen (CA19-9, sialylated Lea) in gastric cancers and normal gastric tissues from 46 patients was analysed using an immunohistological method and a series of mouse monoclonal antibodies. Secretory status was determined by ELISA test on glycoproteins extracted from saliva of a selected number of the patients. In normal gastric tissues, type 1 (lea, Leb) was expressed in the surface epithelium, whereas type 2 (X, Y) was mainly detected in the deep glands. In gasric cancers, experssion and production of Lea and CA19-9 were greatly increased, especilly in secretors, and consistent distribution of Lea and CA19-9 were observed. X, Y as well as Leb were almost similar to normal tissues, but staining pattern of these antigens in cancers was classified as stromal type. High concentration of CA19-9 were found in sera from patients with advanced cancers. Study of those antigens in normal and malignant tissues from the same patient may provide us a clue to understand the anomalous expression in neoplasia.