Details

Autor(en) / Beteiligte

• den Heijer, Martin
• Koster, Ted
• Blom, Henk J
• Bos, Gerard M.J
• Briët, Ernest
• Reitsma, Pieter H
• Vandenbroucke, Jan P
• Rosendaal, Frits R

Titel

Hyperhomocysteinemia as a Risk Factor for Deep-Vein Thrombosis

Ist Teil von

• The New England journal of medicine, 1996-03, Vol.334 (12), p.759-762

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1996

Quelle

MEDLINE

Beschreibungen/Notizen

• Mild hyperhomocysteinemia is an established risk factor for atherosclerosis and vascular disease. 1 , 2 In classic homocystinuria, half the vascular complications are of venous origin, 3 but until recently it has been unclear whether mild hyperhomocysteinemia is also a risk factor for venous thrombosis. 2 , 4 , 5 In a case–control study, Falcon et al. found that hyperhomocysteinemia was a risk factor for thrombosis in people younger than 40 years of age. 6 They reported that the difference in homocysteine levels between case patients and control subjects was particularly evident after methionine loading (since methionine is a precursor of homocysteine). Recently, we found hyperhomocysteinemia to . . .