Details

Autor(en) / Beteiligte

• Szarewski, A
• Sasieni, P
• Edwards, R
• Cuzick, J
• Jarvis, M.J
• Steele, S.J
• Guillebaud, J

Titel

Effect of smoking cessation on cervical lesion size

Ist Teil von

• The Lancet (British edition), 1996-04, Vol.347 (9006), p.941-943

Ort / Verlag

London: Elsevier Ltd

Erscheinungsjahr

1996

Quelle

Psychology & Behavioral Sciences Collection (EBSCOhost)

Beschreibungen/Notizen

• Summary Background Cigarette smoking has been postulated as a cofactor in the aetiology of cervical cancer, but a causal role is difficult to establish because of potential confounding by sexual behaviour. We have investigated the effect of cessation or reduction in cigarette smoking on the course of minor-grade cervical lesions. Methods In this intervention study 82 women volunteers with minor-grade lesions on colposcopy (cervical intraepithelial neoplasia grade 1 or less) attempted to give up smoking for 6 months. Smoking histories were taken at 3-monthly clinic visits and verified by measurement of salivary cotinine concentrations. At each clinic visit, a photograph of the cervix was taken; the image was digitised and computer-aided image analysis was used to assess lesion size, by investigators unaware of smoking status. Findings Of the 82 women, 17 stopped smoking completely for at least 6 months and 11 others reduced their smoking consumption by more than 75%. Of these 28 women, 23 (82%) showed a reduction in lesion size of at least 20% or 4 mm2 compared with 13 (28%) of the 47 non-quitters (odds ratio 12·0 [95% Cl 3·9-32·7]). The remaining seven women had unconfirmed smoking histories. There was a significant correlation between the extent of smoking reduction and the change in lesion size (X 2 for trend=31·55, p<0·0001). Adjustment for social class, method of contraception, and stage of menstrual cycle did not affect the results. Interpretation Our findings support a link between smoking and cervical disease and suggest that smoking cessation could have a beneficial effect on early cervical abnormalities.