Details

Autor(en) / Beteiligte

• RABKIN, C. S
• BEDI, G
• MUSABA, E
• SUNKUTU, R
• MWANSA, N
• SIDRANSKY, D
• BIGGAR, R. J

Titel

AIDS-related Kaposi's sarcoma is a clonal neoplasm

Ist Teil von

• Clinical cancer research, 1995-03, Vol.1 (3), p.257-260

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

1995

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Kaposi's sarcoma is generally believed to be a non-neoplastic hyperproliferation because it may regress spontaneously and its spindle cells lack features of typical tumor cells, such as aneuploidy, nuclear atypia, and permissive growth in cell culture. A fundamental characteristic of neoplasms is clonality, in that they arise from clonal replication of a single cell whereas reactive processes are derived from polyclonal proliferation. We used an X chromosome inactivation assay to determine the clonality of Kaposi's sarcoma nodules from patients with AIDS-related disease. The assay is based on a methyl-sensitive restriction digest followed by PCR amplification of the highly polymorphic androgen receptor gene. Two of three evaluable cases had a monoclonal pattern of inactivation, and the third case had a clonal expansion of cells with an altered microsatellite repeat sequence. These data suggest that Kaposi's sarcoma (at least in the AIDS setting) is a clonal neoplasm.