Nature (London), 1987-12, Vol.330 (6147), p.444-450
1987
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Details
- Autor(en) / Beteiligte
- Titel
- A human retinoic acid receptor which belongs to the family of nuclear receptors
- Ist Teil von
- Nature (London), 1987-12, Vol.330 (6147), p.444-450
- Ort / Verlag
- London: Nature Publishing
- Erscheinungsjahr
- 1987
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A cDNA encoding a protein that binds retinoic acid with high affinity has been cloned. The protein is homologous to the receptors for steroid hormones, thyroid hormones and vitamin D3, and appears to be a retinoic acid-inducible trans-acting enhancer factor, suggesting that the molecular mechanisms of the effect of retinoids (vitamin A) on embryonic development, differentiation and tumour cell growth are similar to those described for other members of this nuclear receptor family.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-0836eISSN: 1476-4687DOI: 10.1038/330444a0Titel-ID: cdi_proquest_miscellaneous_77845015
- Format
- –
- Schlagworte
- Amino Acid Sequence, Base Sequence, Biological and medical sciences, Carrier Proteins - genetics, Carrier Proteins - metabolism, Cell Nucleus - metabolism, Chromosome Mapping, Cloning, Molecular, DNA - genetics, Embryonic growth stage, Fundamental and applied biological sciences. Psychology, Gene expression, Genetics, HeLa Cells, Hormones, Humans, Molecular and cellular biology, Molecular genetics, Molecular Sequence Data, Proteins, Receptors, Retinoic Acid, Steroid hormones, Steroids, Thyroid, Transcription, Genetic - drug effects, Transfection, Tretinoin - metabolism, Tretinoin - pharmacology