Details

Autor(en) / Beteiligte

• Browne, Thomas R.
• Greenblatt, David
• Evans, James E.
• Evans, Barbara A.
• Szabo, George K.
• Schumacher, Gerald E.

Titel

Determination of the in Vivo Km and Vmax of a Drug With Tracer Studies

Ist Teil von

• Journal of clinical pharmacology, 1987-04, Vol.27 (4), p.321-324

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

1987

Quelle

MEDLINE

Beschreibungen/Notizen

• A method is described for determining the in vivo Km and Vmax values for a drug, utilizing a variant of the Michaelis‐Menten equation and the elimination‐rate constants of tracer doses of the drug administered at two different serum concentration values. The new method is the most accurate yet devised; unlike older methods, it is dependent on assumptions that generally are true and can be validated empirically. Application of the method is demonstrated by a study of phenytoin in humans.