Journal of pharmaceutical and biomedical analysis, 1994-12, Vol.12 (12), p.1501-1505
1994
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Details
- Autor(en) / Beteiligte
- Titel
- Effects of drug-binding on the thermal denaturation of human serum albumin
- Ist Teil von
- Journal of pharmaceutical and biomedical analysis, 1994-12, Vol.12 (12), p.1501-1505
- Ort / Verlag
- Amsterdam: Elsevier B.V
- Erscheinungsjahr
- 1994
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Asymmetric thermograms of defatted albumin, alone and in the presence of two model drugs, have been obtained in phosphate buffers at three pH values. The albumin is less thermally stable in the N form, but is protected by both drugs. The nonsteroidal antiinflammatory benoxaprofen offers more protection than warfarin against thermal denaturation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0731-7085eISSN: 1873-264XDOI: 10.1016/0731-7085(94)00094-8Titel-ID: cdi_proquest_miscellaneous_77797680
- Format
- –
- Schlagworte
- Anti-Inflammatory Agents, Non-Steroidal - pharmacology, benoxaprofen, Binding Sites, Biological and medical sciences, Calorimetry, Differential Scanning, conformation, DSC, General pharmacology, HSA, Humans, Medical sciences, Pharmacology. Drug treatments, Physicochemical properties. Structure-activity relationships, Propionates - pharmacology, Protein Denaturation, Serum Albumin - chemistry, stabilization, thermogram, unfolding, warfarin, Warfarin - pharmacology