Details

Autor(en) / Beteiligte

• Oristrell, J.
• Amengual, Mª J.
• Font-Creus, B.
• Casanovas, A.
• Segura-Porta, F.

Titel

Plasma Levels of Tumor Necrosis Factor α in Patients with Mediterranean Spotted Fever: Clinical and Analytical Correlations

Ist Teil von

• Clinical infectious diseases, 1994-12, Vol.19 (6), p.1141-1143

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

1994

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Twenty consecutive patients with serologically confirmed Mediterranean spotted fever were analyzed for determination of plasma levels of tumor necrosis factor α (TNF-α) by means of an ELISA. Increased levels of TNF-α in plasma were found during the acute phase of the disease (52.3 ± 49.8 pg/mL) compared to levels in the convalescent phase (9.0 ± 9.3 pg/mL; P < .001) or in healthy controls (6.5 ± 3.2 pg/mL; P < .001). Plasma TNF-α levels were significantly higher in patients with severe Mediterranean spotted fever. Levels of TNF-α correlated significantly with serum levels of C-reactive protein and triglycerides and inversely with serum levels of sodium.