Details

Autor(en) / Beteiligte

• Beilke, Mark A.
• Greenspan, Debra L.
• Impey, Ann
• Thompson, Jane
• Didier, Peter J.

Titel

Laboratory study of HIV-1 and HTLV-I/II coinfection

Ist Teil von

• Journal of medical virology, 1994-10, Vol.44 (2), p.132-143

Ort / Verlag

New York: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

1994

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A Retroviral Coinfection Clinic was established in 1991 at Charity Hospital Medical Center of Louisiana to study patients dually infected with human immunodeficiency virus (HIV) and human T lymphotropic virus (HTLV‐I, HTLV‐II). Eight patients were evaluated clinically, and by immunological and virological studies. Multiple neuromuscular diseases were observed, including tropical spastic paraparesis, polymyositis, and polyneuropathies. Only one patient developed AIDS. HIV‐1 infected patients with HTLV‐I, but not HTLV‐II, coinfection have maintained stable CD4 counts, despite the fact that quantitative HIV DNA PCR suggests a relatively high copy number. HTLV‐I/II antigens were detected in lymphocyte cultures from four patients, and lymphoblastoid cell lines have been established from two. These results support the contention that upregulated HTLV‐I/II virus expression and disease manifestations occur during coinfection with HIV, sometimes in association with normal CD4 counts. © 1994 Wiley‐Liss, Inc.