Details

Autor(en) / Beteiligte

• Neurath, Markus F.
• Stüber, Eckhard R.
• Strober, Warren

Titel

BSAP: a key regulator of B-cell development and differentiation

Ist Teil von

• Immunology today (Amsterdam. Regular ed.), 1995, Vol.16 (12), p.564-569

Ort / Verlag

England: Elsevier B.V

Erscheinungsjahr

1995

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• B-cell-specific activator protein (BSAP) is a recently identified member of the Pax-gene family of transcription factors; in the lymphoid system, BSAP is produed only in B cells. Here, Markus Neurath, Eckhard Stüber and Warren Strober describe the molecular structure of BSAP and focus on the ability of this protein to regulate the expression of B-cell-specific genes. They propose that BSAP is a key protein of B cells and that it not only influences B-cell development, but also influences the balance between B-cell proliferation and immunoglobulin secretion at later stages of B-cell differentiation.