Details

Autor(en) / Beteiligte

• Lebrun, C. J.
• Möllenhoff, E.
• Bao, G.
• Culman, J.
• Unger, Th

Titel

Angiotensin II Induces the Expression of C-FOS mRNA in the Central Nervous System of the Rat

Ist Teil von

• Clinical and experimental hypertension (1993), 1995, Vol.17 (6), p.877-893

Ort / Verlag

Colchester: Informa UK Ltd

Erscheinungsjahr

1995

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• We have investigated the effects of intracerebroventricular injections of angiotensin II in conscious rats on the expression of c-fos messenger RNA (mRNA) in the caudate nucleus, hypothalamus, midbrain and brainstem using semi-quantitative polymerase chain reaction and Northern Blots. RNA analysis revealed the presence of c-fos transcripts in the midbrain and brainstem following icv injections of ANG II. ANG II (1, 10, 100 ng) induced a substantial increase in c-fos mRNA in the brainstem which was significant after 10 ng ANG II, and less after 100 ng. This effect was time-dependent being detectable within 15 minutes and maximal after 60 minutes. This ANG II-induced c-fos mRNA expression was totally inhibited by icv pretreatment with the ANG II-AT1 receptor antagonist, losartan. Our data show for the first time that stimulation of central periventricular AT1 receptors induces the expression of c-fos mRNA in the brain. Thus, ANG II, in addition to its short-term regulatory actions, can participate through transcription factors in neuroplastic processes.