Journal of medicinal chemistry, 1995-10, Vol.38 (22), p.4503-4507
1995
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Details
- Autor(en) / Beteiligte
- Titel
- Topoisomerase II-Mediated DNA Cleavage by Adocia- and Xestoquinones from the Philippine Sponge Xestospongia sp
- Ist Teil von
- Journal of medicinal chemistry, 1995-10, Vol.38 (22), p.4503-4507
- Ort / Verlag
- Washington, DC: American Chemical Society
- Erscheinungsjahr
- 1995
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Investigation of an orange Xestospongia sp. sponge collected at Cape Bolinao in northern Luzon, Philippines, yielded the known compounds adociaquinones A and B (1, 2) and six new metabolites, secoadociaquinones A and B (3, 4), 14-methoxyxestoquinone (5), 15-methoxyxestoquinone (6), 15-chloro-14-hydroxyxestoquinone (7), and 14-chloro-15-hydroxyxestoquinone (8). All compounds showed inhibition of topoisomerase II in catalytic DNA unwinding and/or decatenation assays. Furthermore, adociaquinone B showed activity in a KSDS assay, suggesting it inhibits the enzyme by freezing the enzyme-DNA cleavable complex. Interestingly, adociaquinone B did not displace ethidium bromide from DNA or unwind supercoiled DNA, implying it does not intercalate DNA.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-2623eISSN: 1520-4804DOI: 10.1021/jm00022a016Titel-ID: cdi_proquest_miscellaneous_77686498
- Format
- –
- Schlagworte
- Animals, Antineoplastic Agents - chemistry, Antineoplastic Agents - isolation & purification, Antineoplastic Agents - pharmacology, Biological and medical sciences, Crystallography, X-Ray, DNA - drug effects, DNA - metabolism, Drug Screening Assays, Antitumor, General pharmacology, Humans, Intercalating Agents, Magnetic Resonance Spectroscopy, Marine, Medical sciences, Molecular Structure, Pharmacognosy. Homeopathy. Health food, Pharmacology. Drug treatments, Philippines, Porifera - chemistry, Quinones - chemistry, Quinones - isolation & purification, Quinones - pharmacology, Topoisomerase II Inhibitors, Tumor Cells, Cultured, Xestospongia