Details

Autor(en) / Beteiligte

• Kida, Elizabeth
• Choi-Miura, Nam-Ho
• Wisniewski, Krystyna E.

Titel

Deposition of apolipoproteins E and J in senile plaques is topographically determined in both Alzheimer's disease and Down's syndrome brain

Ist Teil von

• Brain research, 1995-07, Vol.685 (1), p.211-216

Ort / Verlag

London: Elsevier B.V

Erscheinungsjahr

1995

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The link between the immunolocalization of apolipoproteins E (apo E) and J (apo J) and the different severity of β-amyloid deposition in various areas of Alzheimer's disease (AD) and Down's syndrome (DS) brain was analyzed. Both apolipoproteins were found in all types of senile plaques (SPs) in the cerebral cortex, which is early and severely involved in β-amyloidosis, but apo E was seen more often than apo J in diffuse A β deposits, especially in young DS cases and nondemented elderly persons. In the striatum and cerebellum, which show predominance of diffuse A β deposits throughout the lifespan, apo J was absent, except for few compact deposits, whereas apo E was more widely distributed, apart from diffuse plaques in the striatum. By immunoelectron microscopy, A β fibrils were disclosed in diffuse plaques in all brain regions studied, but not all of these early fibrillar deposits, even in the neocortex of young DS cases, showed apo E and apo J labelling. Thus, our data indicate that the immunoreactivity to apo E and J within A β deposits is topographically determined in both AD and DS brain. Moreover, although it appears that neither of apolipoproteins studied is necessary to initiate A β fibrillogenesis, disclosed topographic dissimilarities of their distribution within parenchymal A β deposits suggest that they may be involved in different ways in the pathogenesis of β-amyloidosis.