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Brazilin stimulates the glucose transport in 3T3-L1 cells
Ist Teil von
Planta medica, 1995-08, Vol.61 (4), p.297-301
Ort / Verlag
Stuttgart: Thieme
Erscheinungsjahr
1995
Quelle
MEDLINE
Beschreibungen/Notizen
Brazilin (7,11b-dihydrobenz(b)indeno(1,2-d)pyran-3,6a, 9,10(6H)-tetrol) was found to have hypoglycemic action and increase glucose metabolism in experimental diabetic animals. In order to investigate the mechanism of hypoglycemic action of brazilin, the effects of brazilin on glucose transport, insulin receptor autophosphorylation, and protein kinase C(PKC) activity in 3T3-L1 cells were studied. Brazilin increased basal glucose transport in 3T3-L1 fibroblasts and adipocytes. However, insulin-stimulated glucose transport was not influenced. Autophosphorylation of the partially purified insulin receptor was not affected by brazilin treatment in 3T3-L1 fibroblasts. However, brazilin decreased the PKC activity in 3T3-L1 fibroblasts and adipocytes.