Planta medica, 1995-08, Vol.61 (4), p.297-301
1995
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Details
- Autor(en) / Beteiligte
- Titel
- Brazilin stimulates the glucose transport in 3T3-L1 cells
- Ist Teil von
- Planta medica, 1995-08, Vol.61 (4), p.297-301
- Ort / Verlag
- Stuttgart: Thieme
- Erscheinungsjahr
- 1995
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Brazilin (7,11b-dihydrobenz(b)indeno(1,2-d)pyran-3,6a, 9,10(6H)-tetrol) was found to have hypoglycemic action and increase glucose metabolism in experimental diabetic animals. In order to investigate the mechanism of hypoglycemic action of brazilin, the effects of brazilin on glucose transport, insulin receptor autophosphorylation, and protein kinase C(PKC) activity in 3T3-L1 cells were studied. Brazilin increased basal glucose transport in 3T3-L1 fibroblasts and adipocytes. However, insulin-stimulated glucose transport was not influenced. Autophosphorylation of the partially purified insulin receptor was not affected by brazilin treatment in 3T3-L1 fibroblasts. However, brazilin decreased the PKC activity in 3T3-L1 fibroblasts and adipocytes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0032-0943eISSN: 1439-0221DOI: 10.1055/s-2006-958087Titel-ID: cdi_proquest_miscellaneous_77649897
- Format
- –
- Schlagworte
- 3T3 Cells, Adipocytes - drug effects, Adipocytes - metabolism, Animals, Benzopyrans - pharmacology, Biological and medical sciences, Biological Transport - drug effects, CAESALPINIA, COMPOSICION QUIMICA, COMPOSITION CHIMIQUE, ESTRUCTURA QUIMICA, FARMACOLOGIA, Fibroblasts - drug effects, Fibroblasts - metabolism, General pharmacology, GLUCOSA, GLUCOSE, Glucose - metabolism, HIPOGLICEMIA, HYPOGLYCEMIE, Insulin - pharmacology, INSULINA, INSULINE, Medical sciences, Mice, Pharmacognosy. Homeopathy. Health food, PHARMACOLOGIE, Pharmacology. Drug treatments, PLANTAS MEDICINALES, PLANTE MEDICINALE, Protein Kinase C - metabolism, PROTEINA QUINASA, PROTEINE KINASE, Receptor, Insulin - metabolism, STRUCTURE CHIMIQUE, TRANSPORT DES SUBSTANCES NUTRITIVES, TRANSPORTE DE NUTRIENTES