Details

Autor(en) / Beteiligte

• Mond, James J.
• Vos, Quirijn
• Lees, Andrew
• Snapper, Clifford M.

Titel

T cell independent antigens

Ist Teil von

• Current opinion in immunology, 1995, Vol.7 (3), p.349-354

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

1995

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• T cell independent antigens type 2 (TI-2), which are represented predominantly by polysaccharide antigens, stimulate humoral antibody responses in the absence of T-cell help. We and others have recently reported that natural killer cells and/or natural killer cell derived lymphokines may provide a form of ‘help’ that is necessary for the induction and maintenance of Tl-2 responses. Two natural killer cell derived lymphokines, interferon-γ and granulocyte-macrophage colony-stimulating factor, show synergistic stimulatory activity in inducing lg secretion in B cells stimulated by a multivalent ligand that mimics Tl-2 antigens. The recent finding that natural killer cells have receptors for various classes of polysaccharides supports a role for these cells in regulating responses to Tl-2 antigens.