Chemical and Pharmaceutical Bulletin, 1995/05/15, Vol.43(5), pp.853-858
1995
Details
- Autor(en) / Beteiligte
- Titel
- Synthesis of Protegrin-Related Peptides and Their Antibacterial and Anti-human Immunodeficiency Virus Activity
- Ist Teil von
- Chemical and Pharmaceutical Bulletin, 1995/05/15, Vol.43(5), pp.853-858
- Ort / Verlag
- Tokyo: The Pharmaceutical Society of Japan
- Erscheinungsjahr
- 1995
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- All disulfide analogs (types I, II and III) of protegrin (PG)-1, an 18-residue antimicrobial peptide having two intramolecular disulfide bonds, were synthesized using regioselective disulfide bond formation. Random air-oxidation of the fully reduced PG-1 formed the type III PG-1. In addition, a type III analog containing an amidated carboxy-terminal residue was also prepared. Each analog showed significant and different antibacterial and anti-human immunodeficiency virus (HIV) activity. Deletion of two disulfide bridges caused a significant decrease in activity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0009-2363eISSN: 1347-5223DOI: 10.1248/cpb.43.853Titel-ID: cdi_proquest_miscellaneous_77628896
- Format
- –
- Schlagworte
- AIDS/HIV, Amino Acid Sequence, Animals, Anti-Bacterial Agents, anti-human immunodeficiency virus activity, Anti-Infective Agents - chemical synthesis, Anti-Infective Agents - pharmacology, Antibiotics. Antiinfectious agents. Antiparasitic agents, antimicrobial activity, Antimicrobial Cationic Peptides, Antiviral agents, Antiviral Agents - chemical synthesis, Antiviral Agents - pharmacology, Biological and medical sciences, Candida albicans - drug effects, defensin, Disulfides - chemical synthesis, Disulfides - pharmacology, Escherichia coli - drug effects, HIV - drug effects, human immunodeficiency virus, Humans, Medical sciences, Microbial Sensitivity Tests, Molecular Sequence Data, Peptides - chemical synthesis, Peptides - pharmacology, Pharmacology. Drug treatments, protegrin, Proteins - chemical synthesis, Proteins - pharmacology, regioselective disulfide bond formation, Salmonella - drug effects, Sequence Homology, Amino Acid, Structure-Activity Relationship, tachyplesin