Details

Autor(en) / Beteiligte

• Kanold, J.
• Berger, M.
• Rapatel, C.
• Lumley, L. de
• Lutz, P.
• Plantaz, D.
• Vannier, J. P.
• Bergeron, C.
• Mechinaud, F.
• Favrot, M.
• Bonhomme, J.
• Travade, P.
• CHRU, F. Demeocq

Titel

CD34+ cell immunoselection from G‐CSF‐alone‐primed peripheral blood in children with low body mass

Ist Teil von

• British journal of haematology, 1995-10, Vol.91 (2), p.431-433

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

1995

Quelle

MEDLINE

Beschreibungen/Notizen

• We report the data of CD34+ cell immunoselection from peripheral blood after G‐CSF‐alone mobilization (lOμg/kg/d s.c.) in nine children with neuroblastoma (median age 4 5 years (2‐8), median body weight 16kg (10‐20). Leukaphereses were carried out on a Cobe Spectra separator and two consecutive harvests (4 blood volumes processed) were used for immunoselection on a Ceprate(tm) column. The yield of CD34+ cells in the purified fraction was 50% (23‐80), with a median number of 2.8xl06 CD34+ cells/kg (1‐9‐4). All patients were reinfused with selected CD34+ cells after busulfan 600 mg/m2+ melphalan 180mg/m2 and achieved successful haemopoietic recovery.