Details

Autor(en) / Beteiligte

• Tanigawa, Nobuhiko
• Shimomatsuya, Takumi
• Takahashi, Kohji
• Inomata, Yukihiro
• Tanaka, Koichi
• Satomura, Kisaku
• Hikasa, Yorinori
• Hashida, Mitsuru
• Muranishi, Shozo
• Sezaki, Hitoshi

Titel

Treatment of cystic hygroma and lymphangioma with the use of bleomycin fat emulsion

Ist Teil von

• Cancer, 1987-08, Vol.60 (4), p.741-749

Ort / Verlag

New York: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

1987

Quelle

MEDLINE

Beschreibungen/Notizen

• Of the several types of treatment for cystic hygromas and lymphangiomas, surgical excision has been the preferred treatment. However, there is a high recurrence rate because lymphangiomas tend to infiltrate the surrounding tissues. Bleomycin in a microsphere‐in‐oil (S/O) emulsion was used in this study as a sclerosing agent for lymphangiomas. Experimental studies using domestic rabbits showed that the bleomycin emulsion caused more marked fibrotic changes at the injection site than other formulations, such as a blank emulsion and bleomycin solution. In clinical trials, 27 of 33 patients received bleomycin S/O emulsion injected directly into the tumors with satisfactory results. Histologic pictures of the clinically resected specimens confirmed the findings of the experimental studies. Comparative studies of treatments between bleomycin S/O emulsion and surgery indicated that injection therapy of bleomycin S/O emulsion would be more beneficial than surgical excisions.