Details

Autor(en) / Beteiligte

• Bosma, Piter J
• Chowdhury, Jayanta Roy
• Chowdhury, Namita Roy
• Bakker, Conny
• Gantla, Shailaja
• de Boer, Anita
• Oostra, Ben A
• Lindhout, Dick
• Tytgat, Guido N.J
• Jansen, Peter L.M
• Elferink, Ronald P.J. Oude

Titel

The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's Syndrome

Ist Teil von

• The New England journal of medicine, 1995-11, Vol.333 (18), p.1171-1175

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1995

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• People with Gilbert's syndrome have mild, chronic unconjugated hyperbilirubinemia in the absence of liver disease or overt hemolysis. 1 , 2 Although the syndrome is inherited, many people do not have a clear family history. 3 An autosomal mode of inheritance has been proposed, 4 and more recently, a recessive pattern of inheritance has been suggested. 5 On the basis of serum bilirubin levels, 3 to 10 percent of the general population are estimated to have Gilbert's syndrome. 6 – 8 Serum bilirubin levels fluctuate in people with Gilbert's syndrome and often fall within accepted normal limits, making it unclear whether these people constitute a distinct subpopulation . . .