Pharmacology, biochemistry and behavior, 1995-06, Vol.51 (2), p.245-247
1995
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- Autor(en) / Beteiligte
- Titel
- The protective effect of moclobemide against hypoxia-induced lethality in mice is not due to a decrease in body temperature
- Ist Teil von
- Pharmacology, biochemistry and behavior, 1995-06, Vol.51 (2), p.245-247
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 1995
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- The protective effect of moclobemide, a reversible and highly selective inhibitor of monoamine oxidase-A, against hypoxia-induced lethality was investigated in the present experiment. Moclobemide showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Hypothermia is known to protect animals from hypoxia. Moclobemide also decreased body temperature in mice; however, the hypothermic effect was unrelated to the antihypoxic effect. These results suggest that the protective effect of moclobemide in hypoxia is not due to a decrease in body temperature.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0091-3057eISSN: 1873-5177DOI: 10.1016/0091-3057(94)00366-QTitel-ID: cdi_proquest_miscellaneous_77509116
- Format
- –
- Schlagworte
- Animals, Anticonvulsants - therapeutic use, Benzamides - therapeutic use, Biological and medical sciences, Body temperature, Body Temperature - drug effects, Dose-Response Relationship, Drug, Hypoxia, Hypoxia - drug therapy, Hypoxia - physiopathology, Male, Medical sciences, Mice, Miscellaneous, Moclobemide, Neuropharmacology, Pharmacology. Drug treatments, Seizures - physiopathology