Science (American Association for the Advancement of Science), 1995-09, Vol.269 (5229), p.1402-1406
1995
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Details
- Autor(en) / Beteiligte
- Titel
- Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein
- Ist Teil von
- Science (American Association for the Advancement of Science), 1995-09, Vol.269 (5229), p.1402-1406
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 1995
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Germline mutations in the von Hippel-Lindau tumor suppressor gene (VHL) predispose individuals to a variety of tumors, including renal carcinoma, hemangioblastoma of the central nervous system, and pheochromocytoma. Here, a cellular transcription factor, Elongin (SIII), is identified as a functional target of the VHL protein. Elongin (SIII) is a heterotrimer consisting of a transcriptionally active subunit (A) and two regulatory subunits (B and C) that activate transcription elongation by RNA polymerase II. The VHL protein was shown to bind tightly and specifically to the Elongin B and C subunits and to inhibit Elongin (SIII) transcriptional activity in vitro. These findings reveal a potentially important transcriptional regulatory network in which the VHL protein may play a key role.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.7660122Titel-ID: cdi_proquest_miscellaneous_77484435
- Format
- –
- Schlagworte
- Amino Acid Sequence, Amino acids, Animals, Biological and medical sciences, Cancer, Carcinogenesis, Cell Line, Cloning, Molecular, Complementary DNA, COS cells, Elongin, Fundamental and applied biological sciences. Psychology, Gene Expression Regulation, Genes, Genes, Tumor Suppressor, Genetic regulation, Genetic transcription, HeLa Cells, Humans, Ligases, Medical research, Molecular and cellular biology, Molecular genetics, Molecular Sequence Data, Mutation, Nuclear Proteins - genetics, Nuclear Proteins - metabolism, Proteins, Recombinant Proteins - metabolism, Regulation, Research Article, Resins, RNA, RNA Polymerase II - metabolism, Transcription (Genetics), Transcription Factors - chemistry, Transcription Factors - isolation & purification, Transcription Factors - metabolism, Transcription, Genetic, Transcription. Transcription factor. Splicing. Rna processing, Translation, Tumor suppressor genes, Tumor Suppressor Proteins, Tumors, Ubiquitin-Protein Ligases, von Hippel-Lindau Disease - genetics, Von Hippel-Lindau Tumor Suppressor Protein