FEBS letters, 1995-08, Vol.370 (3), p.250-254
1995
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Details
- Autor(en) / Beteiligte
- Titel
- The Drosophila learning and memory gene linotte encodes a putative receptor tyrosine kinase homologous to the human RYK gene product
- Ist Teil von
- FEBS letters, 1995-08, Vol.370 (3), p.250-254
- Ort / Verlag
- England: Elsevier B.V
- Erscheinungsjahr
- 1995
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The linotte mutant was isolated on the basis of its learning and memory deficit. Interestingly, linotte individuals carrying a null mutation are viable, indicating that the linotte gene is not required for vital functions. We show here that the linotte gene encodes a putative receptor tyrosine kinase, homologous to the human protein RYK. These products are unique among receptor tyrosine kinases, since they possess a short extra cellular domain, and a modified intracellular catalytic domain. In particular, the subdomains directly involved in ATP binding and phosphotransfer reaction display remarkable variations. These results suggest that linotte is part of a novel signal transduction cascade involved in learning and memory.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/0014-5793(95)00847-3Titel-ID: cdi_proquest_miscellaneous_77476313
- Format
- –
- Schlagworte
- Amino Acid Sequence, Animals, Binding Sites, Central nervous system, DNA Transposable Elements, DNA, Complementary, Drosophila - genetics, Drosophila melanogaster, Genes, Insect, Humans, Introns, Learning - physiology, Learning and memory, Memory - physiology, Molecular Sequence Data, Mutation, Receptor Protein-Tyrosine Kinases - chemistry, Receptor Protein-Tyrosine Kinases - genetics, Receptor Protein-Tyrosine Kinases - metabolism, Receptor tyrosine kinase, Receptors, Cell Surface - chemistry, Sequence Homology, Amino Acid, Signal transduction