Details

Autor(en) / Beteiligte

• Iwata, So
• Ostermeier, Christian
• Ludwig, Bernd
• Michel, Hartmut

Titel

Structure at 2.8 Å resolution of cytochrome c oxidase from Paracoccus denitrificans

Ist Teil von

• Nature (London), 1995-08, Vol.376 (6542), p.660-669

Ort / Verlag

England

Erscheinungsjahr

1995

Quelle

MEDLINE

Beschreibungen/Notizen

• The crystal structure at 2.8 A resolution of the four protein subunits containing cytochrome c oxidase from the soil bacterium Paracoccus denitrificans, complexed with antibody Fv fragment, is described. Subunit I contains 12 membrane-spanning, primarily helical segments and binds haem a and the haem a3-copper B binuclear centre where molecular oxygen is reduced to water. Two proton transfer pathways, one for protons consumed in water formation and one for 'proton pumping', could be identified. Mechanisms for proton pumping are discussed.