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Low proteins C and S and activation of fibrinolysis in treated essential thrombocythemia
American journal of hematology, 1995-08, Vol.49 (4), p.277-281
Wieczorek, Iwona
Macgregor, Ian R.
Ludlam, Christopher A.
1995
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Wieczorek, Iwona
Macgregor, Ian R.
Ludlam, Christopher A.
Titel
Low proteins C and S and activation of fibrinolysis in treated essential thrombocythemia
Ist Teil von
American journal of hematology, 1995-08, Vol.49 (4), p.277-281
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
1995
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
The aim of this study was to investigate whether abnormalities in the fibrinolytic system and in the naturally occurring anticoagulant proteins could contribute to the thrombotic risk in essential thrombocythemia. Euglobulin lysis time, fibrin plate lysis area, tissue plasminogen activator antigen, and activity and plasminogen activator inhibitor antigen were measured before and after venous occlusion in a group of 16 patients with essential thrombocythemia and in 16 healthy age and sex matched controls. In addition, resting levels of antithrombin III, D‐dimer, prothrombin fragment 1 + 2, and protein C and S were assessed. The results were related to the presence or absence of a thrombotic history. The results demonstrated that the patients had a significantly elevated fibrin plate lysis area and significantly decreased plasminogen activator antigen, both at baseline and after venous occlusion. They also had significantly decreased levels of plasma protein C and total protein S. There was a modest, non‐significant elevation in the plasma concentration of D‐Dimer and F 1 + 2. Those patients with a history of thrombosis had significantly lower protein C levels compared with individuals without a thrombotic history. We conclude that patients with essential thrombocythemia have evidence of activated fibrinolysis in the resting state and after stimulation. This, and the decreased levels of protein C and total protein S, may be secondary to chronic clinically occult thrombosis occurring in myeloproliferative disorders. © 1995 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0361-8609
eISSN: 1096-8652
DOI: 10.1002/ajh.2830490404
Titel-ID: cdi_proquest_miscellaneous_77443067
Format
–
Schlagworte
Adult
,
Aged
,
Biological and medical sciences
,
essential thrombocythemia
,
Female
,
Fibrinolysis
,
Hematologic and hematopoietic diseases
,
Humans
,
Male
,
Medical sciences
,
Middle Aged
,
myeloproliferative disorders
,
Platelet diseases and coagulopathies
,
protein C
,
Protein C - analysis
,
protein S
,
Protein S - analysis
,
Thrombocytosis - blood
,
thrombosis
,
Veins - pathology
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