Details

Autor(en) / Beteiligte

• Miñones, J.
• Yebra-Pimentel, E.
• Conde, O.
• Iribarnegaray, E.
• Parada, M. Casas
• Jato, J. L. Vila
• Seijo, B.

Titel

Surface pressure-area isotherms of mixed cyclosporin-poly(isobutylcyanoacrylate) monolayers spread at the air/water interface

Ist Teil von

• Journal of pharmaceutical sciences, 1995-04, Vol.84 (4), p.508-511

Ort / Verlag

Washington: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

1995

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• The π‐A isotherms of mixed monolayers of cyclosporin and poly(isobutylcyanoacrylate) (PIBCA) show that the molecular areas of cyclosporin and PIBCA are additive regardless of the pH of the substrate or the physical state of the monolayers. All these mixed films collapse at the same surface pressure; therefore, application of the two‐dimensional phase rule implies that cyclosporin and PIBCA are immiscible at the interface. This conclusion may have important implications with regard to the formulation of PIBCA–cyclosporin nanoparticles for cyclosporin administration, though further research in this direction will require consideration of the role played by the coadjuvants used for PIBCA polymerization during nanoparticle formation.