Gene, 1995, Vol.159 (2), p.215-218
1995
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- Autor(en) / Beteiligte
- Titel
- Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA
- Ist Teil von
- Gene, 1995, Vol.159 (2), p.215-218
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 1995
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- We report here the nucleotide sequence of a clone, C2H2-34.10, isolated from a human brain cDNA library using degenerate oligodeoxyribonucleotide hybridization. C2H2-34.10 has extensive homology to the Xenopus laevis 5S DNA/ RNA-binding protein, TFIIIA. The deduced amino acid (aa) sequence of the human clone gives a protein of 363 aa with identity to TFIIIA from both X. laevis (57%) and Rana pipiens (59%). This human clone contains nine C2H2-type zinc fingers like frog TFIIIA. Northern blot analysis indicates that the C2H2-34.10 RNA is expressed in human ovary, as well as human neuronal cell lines.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0378-1119eISSN: 1879-0038DOI: 10.1016/0378-1119(95)00145-VTitel-ID: cdi_proquest_miscellaneous_77411172
- Format
- –
- Schlagworte
- Amino Acid Sequence, Animals, Basal transcription factor, Base Sequence, Blotting, Northern, brain, Brain - physiology, DNA, Complementary - genetics, DNA-binding protein, DNA-Binding Proteins - genetics, evolution, Gene Library, homology, Humans, man, Molecular Sequence Data, nucleotide sequence, ovaries, Rana pipiens - genetics, RNA-binding protein, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Tissue Distribution, Transcription Factor TFIIIA, Transcription Factors - genetics, transcription initiation factor TFIIIA, Xenopus laevis, Xenopus laevis - genetics, zinc finger