Details

Autor(en) / Beteiligte

• Harden, P.N
• Rowe, P.A
• Rodger, R.S.C
• Junor, B.J.R
• Briggs, J.D
• Jardine, A.G
• Geddes, C
• Boulton-Jones, M
• Mcllroy, J.H
• Connell, J.M.C

Titel

Polymorphisms in angiotensin-converting-enzyme gene and progression of IgA nephropathy

Ist Teil von

• The Lancet (British edition), 1995-06, Vol.345 (8964), p.1540-1542

Ort / Verlag

London: Elsevier Ltd

Erscheinungsjahr

1995

Link zum Volltext

Quelle

EBSCOhost Business Source Ultimate

Beschreibungen/Notizen

• We have investigated the influence of the functional insertion (I) and deletion (D) polymorphism in intron 16 of the gene for angiotensin-converting enzyme (ACE) in a retrospective study of 100 patients with IgA nephropathy. There was no difference in genotype frequency compared with normal subjects. However, patients homozygous for the D allele tended to present at an earlier age (medians: DD, 33; ID, 34; II, 42 years) and to require renal replacement therapy at a younger age (medians 37, 42, and 48 years, respectively). The rate of progression was significantly worse in patients homozygous for the D allele. The DD genotype is associated with increased severity of disease in patients with IgA nephropathy.