Science (American Association for the Advancement of Science), 1995-06, Vol.268 (5215), p.1343-1347
1995
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Details
- Autor(en) / Beteiligte
- Titel
- Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs
- Ist Teil von
- Science (American Association for the Advancement of Science), 1995-06, Vol.268 (5215), p.1343-1347
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 1995
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.7761853Titel-ID: cdi_proquest_miscellaneous_77293972
- Format
- –
- Schlagworte
- Animals, Antigen presenting cells, Antigen-antibody reactions, antigen-antibody complexes, antibody-complement and others. Study of affinity. Antigen presentation, Antigen-Presenting Cells - immunology, Antigens, Apoptosis, B lymphocytes, Biological and medical sciences, Cell lines, Cellular biology, Cellular immunity, Cytokines, Cytotoxicity, Immunologic, Feedback (Response), Fibroblasts, Fibroblasts - immunology, Fundamental and applied biological sciences. Psychology, Fundamental immunology, Glycoproteins - immunology, Histocompatibility Antigens Class I - immunology, Immune response, L Cells (Cell Line), Logical Thinking, Lymphocytic Choriomeningitis - immunology, Lymphocytic choriomeningitis virus - immunology, Lymphoid tissue, Lymphoid Tissue - immunology, Mice, Mice, Inbred C57BL, Molecular immunology, Molecules, Neoplasms - immunology, T cells, T lymphocytes, T-Lymphocytes, Cytotoxic - immunology, Transfection, Tumor Cells, Cultured, Tumors, Vaccines, Viral Proteins - immunology