Details

Autor(en) / Beteiligte

• WASADA, TARO
• KODAMA, YOSHIFUMI
• INOUE, KAORU
• HISATOMI, AKITAKA
• SAKO, YASUHIRO
• IBAYASHI, HIROSHI

Titel

Plasma Somatostatin Response in Normal and Gastrectomized Subjects

Ist Teil von

• The Tohoku Journal of Experimental Medicine, 1986, Vol.150(2), pp.181-188

Ort / Verlag

Japan: Tohoku University Medical Press

Erscheinungsjahr

1986

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• WASADA, T., KODAMA, Y., INOUE, K., HISATOMI, A., SAKO, Y. and IBAYASHI, H. Plasma Somatostatin Response in Normal and Gastrectomized Subjects. Tohoku J. exp. Med., 1986, 150 (2), 181-188-The present work was undertaken to investigate a possible contribution of the stomach to plasma concentrations of somatostatin-like immunoreactivity (SLI) in humans. For this purpose, plasma SLI responses were determined in previously gastrectomized subjects during lipid-heparin induced elevation of plasma free fatty acids (FFA), which gave a consistent rise of plasma SLI in normal controls. Fasting plasma SLI levels in both the subjects with antral and total gastrectomy did not differ from the values in normal controls. Acute elevation of plasma FFA resulted in about 5-fold increase of plasma SLI above basal level in the controls. In contrast, in both the gastrectomy groups there was no significant rise in plasma SLI, despite a comparable elevation of plasma FFA levels. In conclusion, these findings demonstrate that the stomach, probably the antral region of the stomach, accounts for the most part of increase of plasma SLI when hyperfatty-acidemia is induced and suggest that following the stimulation by nutrients the stomach makes a greater contribution to plasma SLI levels than does the pancreas or extragastric intestinal tract in humans.