Details

Autor(en) / Beteiligte

• Benka, Mary Lynn
• Lee, Matt
• Wang, Guang-Rong
• Buckman, ShaAvhree
• Burlacu, Anda
• Cole, Laura
• DePina, Ana
• Dias, Prabha
• Granger, Aaron
• Grant, Bob
• Hayward-Lester, Amanda
• Karki, Sher
• Mann, Suzanne
• Marcu, Oana
• Nussenzweig, Andre
• Piepenhagen, Peter
• Raje, Manisha
• Roegiers, Fabrice
• Rybak, Sheree
• Salic, Adrian
• Smith-Hall, Jennifer
• Waters, Jennifer
• Yamamoto, Naoyuki
• Yanowitz, Judith
• Yeow, Karen
• Busa, William B.
• Mendelsohn, Michael E.

Titel

The thrombin receptor in human platelets is coupled to a GTP binding protein of the G αq family

Ist Teil von

• FEBS letters, 1995-04, Vol.363 (1), p.49-52

Ort / Verlag

England: Elsevier B.V

Erscheinungsjahr

1995

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• The thrombin receptor is a G protein-coupled receptor, but the G proteins functionally coupled to this receptor in human platelets are not yet definitively identified. Thrombin stimulation of platelets leads to phospholipase C-mediated increases in intracellular calcium, and previous studies have suggested that the thrombin receptor is coupled to members of the G q family. We now demonstrate direct GTPase activation by thrombin receptor activation peptide (TRAP) in human platelet membranes, and specific inhibition of TRAP-activated GTPase by antibodies to G q. These data demonstrate functional coupling of the thrombin receptor to a member of the G q family.