Details

Autor(en) / Beteiligte

• Mark, Daniel B
• Hlatky, Mark A
• Califf, Robert M
• Naylor, C. David
• Lee, Kerry L
• Armstrong, Paul W
• Barbash, Gabriel
• White, Harvey
• Simoons, Maarten L
• Nelson, Charlotte L
• Clapp-Channing, Nancy
• Knight, J. David
• Harrell, Frank E
• Simes, John
• Topol, Eric J

Titel

Cost Effectiveness of Thrombolytic Therapy with Tissue Plasminogen Activator as Compared with Streptokinase for Acute Myocardial Infarction

Ist Teil von

• The New England journal of medicine, 1995-05, Vol.332 (21), p.1418-1424

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1995

Quelle

MEDLINE

Beschreibungen/Notizen

• The value of thrombolytic therapy for patients with acute myocardial infarction has been firmly established. To identify the thrombolytic approach that most effectively produces sustained patency of the infarct-related artery and improves survival, the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO) investigators compared four different regimens: accelerated tissue plasminogen activator (t-PA), streptokinase with intravenous heparin, streptokinase with subcutaneous heparin, and a combination of t-PA and streptokinase. 1 (“Accelerated” refers to the administration of t-PA over a period of 11/2 hours — with two thirds of the dose given in the first 30 minutes — rather . . .