Science (American Association for the Advancement of Science), 1995-03, Vol.267 (5206), p.2000-2003
1995
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme
- Ist Teil von
- Science (American Association for the Advancement of Science), 1995-03, Vol.267 (5206), p.2000-2003
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 1995
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The interleukin-1β (IL-1β) converting enzyme (ICE) processes the inactive IL-1β precursor to the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE gene (ICE$^{-/-}$) did not export IL-1β or interleukin-1α (IL-1α) after stimulation with lipopolysaccharide. Export of tumor necrosis factor-α and interleukin-6 (IL-6) from these cells was also diminished. Thymocytes from ICE$^{-/-}$ mice were sensitive to apoptosis induced by dexamethasone or ionizing radiation, but were resistant to apoptosis induced by Fas antibody. Despite this defect in apoptosis, ICE$^{-/-}$ mice proceed normally through development.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.7535475Titel-ID: cdi_proquest_miscellaneous_77196861
- Format
- –
- Schlagworte
- Amino Acid Sequence, Animals, Antibodies, Antibodies, Monoclonal - immunology, Antigens, Surface - immunology, Apoptosis, Apoptosis - drug effects, Apoptosis - radiation effects, Base Sequence, Biological and medical sciences, Caspase 1, Cell physiology, Cells, Cultured, Chimera, Cysteine Endopeptidases - deficiency, Cysteine Endopeptidases - metabolism, Cytokines, Cytokines - metabolism, Dexamethasone - pharmacology, Exons, fas Receptor, Female, Fundamental and applied biological sciences. Psychology, Ice, Interleukin-1 - metabolism, Ionizing radiation, Lipopolysaccharides - pharmacology, Male, Mice, Mice, Inbred C57BL, Molecular and cellular biology, Molecular Sequence Data, Monocytes, Monocytes - immunology, Nigericin - pharmacology, Responses to growth factors, tumor promotors, other factors, T lymphocytes, T-Lymphocytes - cytology, Thymocytes