Details

Autor(en) / Beteiligte

• Liu, Bo
• Nicolaides, Nicholas C
• Markowitz, Sanford
• Willson, James K.V
• Parsons, Ramon E
• Jen, Jin
• Papadopolous, Nickolas
• Peltomäki, Päivi
• de la Chapelle, Albert
• Hamilton, Stanley R
• Kinzler, Kenneth W
• Vogelstein, Bert

Titel

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

Ist Teil von

• Nature genetics, 1995-01, Vol.9 (1), p.48-55

Ort / Verlag

London: Nature Publishing Group

Erscheinungsjahr

1995

Quelle

MEDLINE

Beschreibungen/Notizen

• Microsatellite instability has been observed in both sporadic and hereditary forms of colorectal cancer. In the hereditary form, this instability is generally due to germline mutations in mismatch repair (MMR) genes. However, only one in ten patients with sporadic tumours exhibiting microsatellite instability had a detectable germline mutation. Moreover, only three of seven sporadic tumour cell lines with microsatellite instability had mutations in a MMR gene, and these mutations could occur somatically. These results demonstrate that tumours can acquire somatic mutations that presumably do not directly affect cell growth but result only in genetic instability. They also suggest that many sporadic tumours with microsatellite instability have alterations in genes other than the four now known to participate in MMR.