Details

Autor(en) / Beteiligte

• Mobilio, S.
• Tondelli, L.
• Capobianco, M.
• Gia, O.

Titel

SEQUENCE SPECIFICITY OF TETRAHYDROBENZOPSORALEN PHOTOBINDING TO DNA

Ist Teil von

• Photochemistry and photobiology, 1995-02, Vol.61 (2), p.113-117

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

1995

Quelle

MEDLINE

Beschreibungen/Notizen

• — The sequence specificity of photobinding to DNA of two tetrahydrobenzopsoralen derivatives has been investigated by testing the photoreactivity toward a number of self‐complementary oligonucleotides. The thermodynamic constant for noncovalent binding to each DNA sequence was evaluated. The extent of photoreactivity was greatly dependent upon base composition. The two tetracyclic compounds show similar behavior in comparison to other bifunctional derivatives. Their overall rate constants were greatly enhanced in comparison to classical psoralens. However, their high efficiency of covalent binding is counterbalanced by low affinity for noncovalent interaction with DNA.