Details

Autor(en) / Beteiligte

• Lekanne Deprez, Ronald H
• Riegman, Peter H
• van Drunen, Ellen
• Warringa, Ursula L
• Groen, Nicole A
• Stefanko, Stanislaw Z
• Koper, Jan W
• Avezaat, Cees J. J
• Zwarthoff, Ellen C
• Hagemeizer, Anne

Titel

Cytogenetic, Molecular Genetic and Pathological Analyses in 126 Meningiomas

Ist Teil von

• Journal of neuropathology and experimental neurology, 1995-03, Vol.54 (2), p.224-235

Ort / Verlag

Hagerstown, MD: American Association of Neuropathologists, Inc

Erscheinungsjahr

1995

Quelle

MEDLINE

Beschreibungen/Notizen

• In a series of 126 meningiomas, tumor and patient charactersitics were investigated and statistically analyzed. A combined cytogenetic and molecular genetic approach was used to study chromosomal abnormalities and loss of markers on chromosome 22q. This apprach was successfully applied to 93 meningiomas. In 66 cases, complete or partial loss of chromosome 22 was observed and in at least 12 of them this chromosome was involved in structural aberrations. In addition to chromosome 22 changes, chromosomes 1, 6, 11, 13, 14, 18, 19, X, and Y were also frequently involved in structural and numerical aberrations. Statistical analysis revealed a significant association between the number of choromosomal abnormalities and tumor grade. Complex karyotypes predominated in the group of grade II/III meningiomas. Furthermore, other variables showed statistically (or marginally statistically) significant differences. Meningiomas from the convexity were more ofthen grade II/III, displayed predominantly (partial) loss of chromosome 22 and had complex karyotypes more often. These fetures were frequently found in meningiomas from males. Base meningiomas, on the other hand, occurred more often in females; they were usually grade I, showed loss of (parts of) chromosome 22 less often and displayed fewer additional chromosomal abnormalities.