Details

Autor(en) / Beteiligte

• Gould, Steven A
• Sehgal, Lakshman R
• Rosen, Arthur L
• Sehgal, Hansa L
• Moss, Gerald S

Titel

The development of polymerized pyridoxylated hemoglobin solution as a red cell substitute

Ist Teil von

• Annals of emergency medicine, 1986-12, Vol.15 (12), p.1416-1419

Ort / Verlag

United States: Mosby, Inc

Erscheinungsjahr

1986

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Development continues for a safe and effective hemoglobin solution to be used as a temporary red cell substitute. Our own efforts have progressed from the unmodified tetramer, to the pyridoxylated tetramer, to our current product — polymerized, pyridoxylated hemoglobin (Poly SFH-P). We recently completed two studies to evaluate the efficacy of Poly SFH-P. The results document that Poly SFH-P supports life in the absence of red cells while maintaining baseline hemodynamics and O 2 consumption. In addition, Poly SFH-P achieves a near-normal plasma [Hb], and has a longer intravascular persistence than any unpolymerized product. Poly SFH-P thus is an improved red cell substitute for use in the clinical setting.