Details

Autor(en) / Beteiligte

• Mack, Thomas M
• Cozen, Wendy
• Shibata, Darryl K
• Weiss, Lawrence M
• Nathwani, Bharat N
• Hernandez, Antonio M
• Taylor, Clive R
• Hamilton, Ann S
• Deapen, Dennis M
• Rappaport, Edward B

Titel

Concordance for Hodgkin's Disease in Identical Twins Suggesting Genetic Susceptibility to the Young-Adult Form of the Disease

Ist Teil von

• The New England journal of medicine, 1995-02, Vol.332 (7), p.413-419

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1995

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Hodgkin's disease is likely to have different causes in young adulthood and old age. 1 The characteristic clinical presentation and histopathological appearance suggest that in young adults the disease is initiated by an environmental exposure, possibly to an infectious agent. The age-specific incidence during young adulthood varies over time and according to place and social class, much like that of infections. Those affected have a small average number of siblings, may not have had the common childhood infections, and are likely to have a history of infectious mononucleosis. 2 These findings have been interpreted to suggest that Hodgkin's disease may occur as . . .