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Advances in space research, 1994-01, Vol.14 (8), p.5-9
Ort / Verlag
England: Elsevier Ltd
Erscheinungsjahr
1994
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
B6MP102 cells, a continuously cultured murine bone marrow macrophage cell line, were tested for secretion of tumor necrosis factor-α and Interleukin-1 during space flight. We found that B6MP102 cells secreted more tumor necrosis factor-α and interleukin-1 when stimulated in space with lipopolysaccharide than controls similarly stimulated on earth. This compared to increased secretion of interferon-beta and -gamma by lymphocytes that was measured on the same shuttle flights. Although space flight enhanced B6MP102 secretion of tumor necrosis factor-α, an experiment on a subsequent space flight (STS-50) found that cellular cytotoxicity, mediated by tumor necrosis factor-α, was inhibited.