Advances in space research, 1994-01, Vol.14 (8), p.5-9
1994
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Details
- Autor(en) / Beteiligte
- Titel
- Production and action of cytokines in space
- Ist Teil von
- Advances in space research, 1994-01, Vol.14 (8), p.5-9
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 1994
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- B6MP102 cells, a continuously cultured murine bone marrow macrophage cell line, were tested for secretion of tumor necrosis factor-α and Interleukin-1 during space flight. We found that B6MP102 cells secreted more tumor necrosis factor-α and interleukin-1 when stimulated in space with lipopolysaccharide than controls similarly stimulated on earth. This compared to increased secretion of interferon-beta and -gamma by lymphocytes that was measured on the same shuttle flights. Although space flight enhanced B6MP102 secretion of tumor necrosis factor-α, an experiment on a subsequent space flight (STS-50) found that cellular cytotoxicity, mediated by tumor necrosis factor-α, was inhibited.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0273-1177eISSN: 1879-1948DOI: 10.1016/0273-1177(94)90380-8Titel-ID: cdi_proquest_miscellaneous_77112993
- Format
- –
- Schlagworte
- Animals, Bone Marrow - metabolism, Bone Marrow - physiology, Bone Marrow Cells, Cell Line, Cytokines - metabolism, Cytokines - physiology, Cytotoxicity, Immunologic, Interferon-beta - metabolism, Interferon-beta - physiology, Interferon-gamma - metabolism, Interferon-gamma - physiology, Interleukin-1 - metabolism, Interleukin-1 - physiology, Lipopolysaccharides - pharmacology, Macrophages - cytology, Macrophages - drug effects, Macrophages - physiology, Mice, Space Flight, Space life sciences, T-Lymphocytes, Cytotoxic - cytology, T-Lymphocytes, Cytotoxic - drug effects, T-Lymphocytes, Cytotoxic - physiology, Tumor Necrosis Factor-alpha - metabolism, Tumor Necrosis Factor-alpha - pharmacology, Tumor Necrosis Factor-alpha - physiology, Weightlessness