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Histamine antagonists and d-tubocurarine-induced hypotension in cardiac surgical patients
Ist Teil von
Clinical pharmacology and therapeutics, 1986-11, Vol.40 (5), p.575-580
Ort / Verlag
New York, NY: Nature Publishing
Erscheinungsjahr
1986
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Hemodynamic effects and histamine release by bolus injection of 0.35 mg/kg of d‐tubocurarine were studied in 24 patients. H1‐ and H2‐histamine antagonists or placebo were given before dosing with d‐tubocurarine in a randomized double‐blind fashion to four groups: group 1—placebo; group 2— cimetidine, 4 mg/kg, plus placebo; group 3—chlorpheniramine, 0.1 mg/kg, plus placebo; and group 4— cimetidine plus chlorpheniramine. Histamine release occurred in most patients, the highest level 2 minutes after d‐tubocurarine dosing. Group 1 had a moderate negative correlation between plasma histamine change and systemic vascular resistance (r = 0.58; P < 0.05) not present in group 4. Prior dosing with antagonists partially prevented the fall in systemic vascular resistance. These data demonstrate that the hemodynamic changes associated with d‐tubocurarine dosing are only partially explained by histamine release. Thus prior dosing with H1‐ and H2‐antagonists provides only partial protection.
Clinical Pharmacology and Therapeutics (1986) 40, 575–580; doi:10.1038/clpt.1986.226