The Lancet (British edition), 1995-01, Vol.345 (8941), p.29-30
1995
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Details
- Autor(en) / Beteiligte
- Titel
- Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer
- Ist Teil von
- The Lancet (British edition), 1995-01, Vol.345 (8941), p.29-30
- Ort / Verlag
- London: Elsevier Ltd
- Erscheinungsjahr
- 1995
- Quelle
- EBSCOhost Psychology and Behavioral Sciences Collection
- Beschreibungen/Notizen
- We treated 19 patients with advanced breast cancer resistant to tamoxifen with a new specific antioestrogen (ICI 182780) which, in animal studies, has no agonist activity. 13 (69%) patients responded (7 had partial responses and 6 showed no change) to monthly intramuscular injections of ICI 182780 after progression on tamoxifen, for a median duration of 18 months with minimum side effects. Preliminary evidence suggests that the agent is without effects on the liver or the hypothalamic-pituitary axis. ICI 182780 appears to be a promising new agent for treatment of advanced and early breast cancer.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0140-6736eISSN: 1474-547XDOI: 10.1016/S0140-6736(95)91156-1Titel-ID: cdi_proquest_miscellaneous_77090783
- Format
- –
- Schlagworte
- Aged, Aged, 80 and over, Antineoplastic agents, Antineoplastic Agents - therapeutic use, Biological and medical sciences, Breast cancer, Breast Neoplasms - drug therapy, Chemotherapy, Drug therapy, Drug Tolerance, Estradiol - analogs & derivatives, Estradiol - therapeutic use, Estrogen Antagonists - therapeutic use, Estrogens, Female, Fulvestrant, Humans, Injections, Intramuscular, Medical research, Medical sciences, Pharmacology. Drug treatments, Tamoxifen - pharmacology