Details

Autor(en) / Beteiligte

• Salvanet, A.
• Fisch, A
• Lafaix, C.
• Montay, G
• Dubayle, P.
• Forestier, F.
• Harocbe, G.

Titel

Pefloxacin concentrations in human aqueous humour and lens

Ist Teil von

• Journal of antimicrobial chemotherapy, 1986-08, Vol.18 (2), p.199-201

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

1986

Quelle

MEDLINE

Beschreibungen/Notizen

• In 20 patients undergoing cataract extraction, we measured pefloxacin concentrations in the eye. After a 1 h infusion of pefloxacin 400 mg iv, the mean pefloxacin concentrations 2, 6, 12 and 24 h post-infusion were 0.75, 1.45, 1.04 and 0.86 mg/l, respectively, The simultaneous mean pefloxacin concentrations in the lens were 0.09, 0.20, 0.26 and 0.43 mg/1, respectively. The adequate penetration of pefloxacin into uninfected aqueous humour and lens suggests that this antibiotic may be effective in the treatment of certain bacterial endophthalmic infections.