Details

Autor(en) / Beteiligte

• Sekher Pannala, Ananth
• Chan, Tom S.
• O'Brien, Peter J.
• Rice-Evans, Catherine A.

Titel

Flavonoid B-Ring Chemistry and Antioxidant Activity: Fast Reaction Kinetics

Ist Teil von

• Biochemical and biophysical research communications, 2001-04, Vol.282 (5), p.1161-1168

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2001

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Rapid scavenging of the model stable radical cation, ABTS•+, has been applied to screen for the antioxidant activity of flavonoids. The reaction follows two distinct phases. For compounds with a monophenolic B-ring there is a rapid initial phase of reduction of ABTS•+ within 0.1 s with no further change in the subsequent 2.9 s. In contrast, compounds with a catechol-containing B ring follow a fast initial scavenging phase with a slow secondary phase. Flavonoids with an unsubstituted B ring do not react within this time scale. The findings suggest that the structure of the B ring is the primary determinant of the antioxidant activity of flavonoids when studied through fast reaction kinetics.