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BibTeX
Post-radiotherapy contrast enhancement changes in fast dynamic MRI of cervical carcinoma
Journal of magnetic resonance imaging, 2001-04, Vol.13 (4), p.600-606
Boss, Erik A.
Massuger, Leon F.A.G.
Pop, Luc A.M.
Verhoef, Lia C.G.
Huisman, Henk-Jan
Boonstra, Henk
Barentsz, Jelle O.
2001
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Boss, Erik A.
Massuger, Leon F.A.G.
Pop, Luc A.M.
Verhoef, Lia C.G.
Huisman, Henk-Jan
Boonstra, Henk
Barentsz, Jelle O.
Titel
Post-radiotherapy contrast enhancement changes in fast dynamic MRI of cervical carcinoma
Ist Teil von
Journal of magnetic resonance imaging, 2001-04, Vol.13 (4), p.600-606
Ort / Verlag
New York: John Wiley & Sons, Inc
Erscheinungsjahr
2001
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
This pilot study determines fast dynamic gadolinium enhanced MRI contrast enhancement parameters (onset of enhancement and time to peak enhancement) before and after radiotherapy in 10 cervical carcinoma patients. Before radiotherapy, onset of enhancement and time to peak enhancement were early, with a median of 4.5 and 5.2 seconds, respectively. High‐grade tumors showed early enhancement, compared with low‐grade. After radiotherapy, contrast enhancement patterns differed. In survivors, onset of enhancement after radiotherapy was later than before radiotherapy. In non‐survivors, onset of enhancement after radiotherapy was still early. The median difference in onset of enhancement before and after radiotherapy in survivors and non‐survivors was an increase of 3.2 and a decrease of 1.1 seconds, respectively. Early onset of enhancement after radiotherapy was a better predictor for survival than a high‐signal intensity zone on post radiotherapy unenhanced T1/T2‐weighted MRI. It is concluded that enhancement parameters from fast dynamic Gd‐enhanced MR images can provide additional functional information with regard to tumor vascularization, and may have prognostic significance. It complements clinical examination and unenhanced MRI in determining the effectiveness of radiotherapy treatment in cervical carcinoma. Future studies will focus on the clinical utility and improvements of the estimation of contrast‐enhanced parameters with this new technique. J. Magn. Reson. Imaging 2001;13:600–606. © 2001 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1053-1807
eISSN: 1522-2586
DOI: 10.1002/jmri.1084
Titel-ID: cdi_proquest_miscellaneous_77008666
Format
–
Schlagworte
contrast enhancement
,
Contrast Media - administration & dosage
,
Female
,
gadolinium
,
Gadolinium DTPA - administration & dosage
,
Humans
,
Magnetic Resonance Imaging - methods
,
MRI
,
Pilot Projects
,
radiotherapy
,
Statistics, Nonparametric
,
Treatment Outcome
,
uterine cervical cancer
,
Uterine Cervical Neoplasms - blood supply
,
Uterine Cervical Neoplasms - pathology
,
Uterine Cervical Neoplasms - radiotherapy
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