Science (American Association for the Advancement of Science), 2001-03, Vol.291 (5512), p.2351-2356
2001
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Details
- Autor(en) / Beteiligte
- Titel
- Glycoprotein Structure Determination by Mass Spectrometry
- Ist Teil von
- Science (American Association for the Advancement of Science), 2001-03, Vol.291 (5512), p.2351-2356
- Ort / Verlag
- United States: American Society for the Advancement of Science
- Erscheinungsjahr
- 2001
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The human genome encodes 30,000 to 40,000 proteins, and a major challenge is to understand how posttranslational events, such as glycosylation, affect the activities and functions of these proteins in health and disease. Glycosylated proteins are ubiquitous components of extracellular matrices and cellular surfaces where their oligosaccharide moieties are implicated in a wide range of cell-cell and cell-matrix recognition events. The power of ultrahigh-sensitivity mass spectrometric strategies for defining the primary structures of highly complex mixtures of glycoprotein glycoforms is set to revolutionize structural glycobiology in the coming postgenomic era.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1058890Titel-ID: cdi_proquest_miscellaneous_77003112
- Format
- –
- Schlagworte
- Analysis, Animals, Carbohydrate Metabolism, Inborn Errors - metabolism, Carbohydrates, Chemistry, Physical and theoretical, Female, Genomics, Glycodelin, Glycoproteins, Glycoproteins - chemistry, Glycoproteins - metabolism, Glycosylation, Humans, Insect antennae, Ionization, Ions, Mass spectrometers, Mass spectrometry, Mass Spectrometry - methods, Mass spectroscopy, Molecules, Mucins, Mucins - chemistry, Oligosaccharides, Peptides, Physical chemistry, Pregnancy, Pregnancy Proteins - chemistry, Pregnancy Proteins - metabolism, Prions - chemistry, Prions - metabolism, Protein Processing, Post-Translational, Proteins, Reviews, Scientific imaging, Spectrometry, Mass, Electrospray Ionization, Spectrometry, Mass, Fast Atom Bombardment, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Sugar, Sugars