Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2001-02, Vol.128 (2), p.221-232
Ort / Verlag
England: Elsevier Inc
Erscheinungsjahr
2001
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
We evaluated the composition of dermatan sulfates (DS) derived from 23 samples of normal and 23 samples of scarred fascia lata. We analyzed the molecular weight of intact DS chains and the length of chain regions comprising: (1) clusters of
l-iduronate-containing disaccharides (‘iduronic sections’); (2) clusters of
d-glucuronate-containing disaccharides (‘glucuronic sections’); and (3) copolymeric sections with both types of disaccharides. A portion of scarred fascia DS chains demonstrated higher molecular weight compared with those from normal tissue. Most disaccharides of DS chains derived from both fascia types form copolymeric segments — heterogeneous in size — with alternatively distributed single disaccharides with glucuronic residues and mainly single ones with iduronate. Only a small number of disaccharides form ‘glucuronic sections’ of heterogeneous size or short ‘iduronic sections’. However, the scarred fascia DS chains demonstrate an increased content of shorter ‘glucuronic sections’ and shorter, often oversulfated, copolymeric segments. It seems that in normal fascia, the DS chain type with a single, long copolymeric region and a single, shorter ‘glucuronic section’ is predominant, while in scarred tissue an increase in multidomain DS chain content may occur.