Details

Autor(en) / Beteiligte

• Iyengar, Smriti
• Kim, Helen S.
• Wood, Paul L.

Titel

Effects of kappa opiate agonists on neurochemical and neuroendocrine indices: Evidence for kappa receptor subtypes

Ist Teil von

• Life sciences (1973), 1986-08, Vol.39 (7), p.637-644

Ort / Verlag

Amsterdam: Elsevier Inc

Erscheinungsjahr

1986

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Four kappa opiate agonists, U-50488H, MR-2034, EKC and tifluadom, elevated plasma corticosterone and decreased plasma TSH in a dose-dependent manner. These effects were naloxone-reversible. However, WIN 44441-3, a long acting narcotic antagonist, was unable to reverse the effects of U-50488H and MR-2034 upto doses of 5 mg/kg. U-50488H and MR-2034 but not tifluadom or EKC, also increased levels of DOPAC and HVA in the olfactory tubercle. This effect was also naloxone-reversible but not WIN 44441-3 reversible. Tifluadom and EKC did not increase DOPAC and HVA. The differential responses of the tested kappa agonists to WIN 44441-3 antagonism and dopamine metabolism in A10 neurons suggest that the kappa agonists can be separated into two groups. This is the first physiological evidence suggestive of kappa opioid receptor subtypes.