Details

Autor(en) / Beteiligte

• Dirren, H
• Logman, M.H.G.M
• Barclay, D.V
• Freire, W.B

Titel

Altitude correction for hemoglobin

Ist Teil von

• European journal of clinical nutrition, 1994-09, Vol.48 (9), p.625-632

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

1994

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective: To propose a correction for the hemoglobin (Hb) increase induced by altitude-associated hypoxia Design: Part of a national study of nutrition and health of preschool children (0-59 months), based on a stratified, probabilistic, cluster sample. Setting: Coastal and Andean regions of Ecuador, comprising about 97% of the population, living at altitudes ranging from sea level to 3400 m. Subjects: Subsample of 469 girls and boys, 6-59 months old, with normal iron (Fe) status parameters, i.e. serum ferritin greater than or equal to 10 micrograms/l, transferrin saturation greater than or equal to 12%, zinc protoporphyrin less than or equal to 2.8 micrograms/g Hb. Results: Exponential regression curves are adapted through the Hb values of the children, grouped by altitude ranges, and through the data reported by Hurtado in 1945 for male adults. From these exponential curves, correction factors for Hb are derived for altitudes ranging from sea level to 3400 m. Conclusion: The striking parallelism between the hypoxia-induced hemoglobin increase with altitude in young children (girls and boys) and that in male adults strongly suggests that the proposed correction factors for Hb are applicable for all ages and possibly both genders, at least in the Andes.