Science (American Association for the Advancement of Science), 1994-12, Vol.266 (5192), p.1862-1865
1994
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Details
- Autor(en) / Beteiligte
- Titel
- An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins
- Ist Teil von
- Science (American Association for the Advancement of Science), 1994-12, Vol.266 (5192), p.1862-1865
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 1994
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that participate in signaling by growth factors and oncogenes. A protein domain was identified that bound specifically to the tyrosine-phosphorylated form of its target protein but differs from known SH2 sequences. Phosphotyrosine-binding (PTB) domains were found in two proteins: SHC, a protein implicated in signaling through Ras; and SCK, encoded by a previously uncharacterized gene. The PTB domain of SHC specifically bound to a tyrosine-phosphorylated 145-kilodalton protein. PTB domains are an alternative to SH2 domains for specifically recruiting tyrosine-phosphorylated proteins into signaling complexes and are likely to take part in signaling by many growth factors.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.7527937Titel-ID: cdi_proquest_miscellaneous_76897196
- Format
- –
- Schlagworte
- 3T3 Cells, Adaptor Proteins, Signal Transducing, Adaptor Proteins, Vesicular Transport, Amino Acid Sequence, Amino acids, Animals, B lymphocytes, Biological and medical sciences, Cell growth, Cell Line, Cell physiology, Cellular immunity, Cellulose nitrate, Fundamental and applied biological sciences. Psychology, Growth factors, Humans, man, Mice, Molecular and cellular biology, Molecular Sequence Data, Molecules, Oncogenes, Phosphatases, Phosphoproteins - metabolism, Phosphorylation, Phosphotyrosine, Platelet-Derived Growth Factor - pharmacology, Protein Binding, Protein tyrosine kinase, Protein-Tyrosine Kinases - chemistry, Protein-Tyrosine Kinases - metabolism, Proteins - chemistry, Proteins - metabolism, SCK protein, SHC protein, Shc Signaling Adaptor Proteins, Signal Transduction, Sodium, Src Homology 2 Domain-Containing, Transforming Protein 1, Stem cells, T lymphocytes, The Clementine Missions, tyrosine, Tyrosine - analogs & derivatives, Tyrosine - metabolism