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Distribution of nitric oxide synthase-immunoreactive interneurons in the spinal trigeminal nucleus
Journal of comparative neurology (1911), 1994-08, Vol.346 (3), p.449-460
Dohrn, C. S.
Mullett, M. A.
Price, R. H.
Beitz, A. J.
1994
Details
Autor(en) / Beteiligte
Dohrn, C. S.
Mullett, M. A.
Price, R. H.
Beitz, A. J.
Titel
Distribution of nitric oxide synthase-immunoreactive interneurons in the spinal trigeminal nucleus
Ist Teil von
Journal of comparative neurology (1911), 1994-08, Vol.346 (3), p.449-460
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
1994
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
The spinal trigeminal nucleus is involved in the transmission of orofacial sensory information. Neither the distribution of the neuromessenger, nitric oxide, within the trigeminal system nor the possible relationship of this simple gas with trigeminothalamic neurons has been carefully studied. Using immunocytochemical (against nitric oxide synthase) and histochemical (NADPH‐diaphorase staining) techniques, we have found that nitric oxide neurons and processes are more prominent in the nucleus caudalis and the dorsomedial aspect of the nucleus oralis than in other spinal trigeminal regions. To study the relationship of nitric oxide to trigeminothalamic neurons and intertrigeminal interneurons of the spinal trigeminal nucleus, spinal trigeminal neurons were retrogradely labeled with fluorogold by thalamic injections or by injections into the junction of the nucleus interpolaris and nucleus caudalis. Medullary sections were subsequently processed with NADPH‐diaphorase histochemistry. None of the diaphorase‐stained neurons in the spinal trigeminal nucleus was found to contain fluorogold; however, some diaphorase‐stained processes were found in close proximity to trigeminothalamic neurons. Following spinal trigeminal nucleus injections, many diaphorasestained neurons were found to contain fluorogold, especially in the nucleus caudalis, suggesting that nitric oxide‐containing neurons in the spinal trigeminal nucleus are intertrigeminal interneurons. Collectively, these data indicate that nitric oxide is most prominent in interneurons located in nucleus caudalis and that these interneurons give rise to processes that appose trigeminothalamic neurons, raising the possibility that they may indirectly influence orofacial nociceptive processing at the level of the spinal trigeminal nucleus via nitric oxide production. © 1994 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0021-9967
eISSN: 1096-9861
DOI: 10.1002/cne.903460308
Titel-ID: cdi_proquest_miscellaneous_76886365
Format
–
Schlagworte
Amino Acid Oxidoreductases - analysis
,
Animals
,
brainstem
,
Histocytochemistry
,
Immunohistochemistry
,
interneuron
,
Interneurons - cytology
,
Interneurons - enzymology
,
NADPH Dehydrogenase - analysis
,
NADPH-diaphorase
,
Nitric Oxide Synthase
,
Rats
,
Rats, Sprague-Dawley
,
Thalamus - anatomy & histology
,
Thalamus - cytology
,
Thalamus - enzymology
,
trigeminal nuclei
,
Trigeminal Nucleus, Spinal - anatomy & histology
,
Trigeminal Nucleus, Spinal - enzymology
,
trigeminothalamic
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