Pharmacology & therapeutics (Oxford), 1994-01, Vol.62 (1), p.1-27
1994
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Details
- Autor(en) / Beteiligte
- Titel
- Melanocortins as factors in somatic neuromuscular growth and regrowth
- Ist Teil von
- Pharmacology & therapeutics (Oxford), 1994-01, Vol.62 (1), p.1-27
- Ort / Verlag
- Amsterdam: Elsevier Inc
- Erscheinungsjahr
- 1994
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Melanocortins, non-corticotropic fragments of adrenorecorticotropic hormone, accelerate growth fo the developing neuromuscular system and regrowth of damaged neurons, both in teh adult and neonatal rat. Morphological, electrophysiological and behavioral characteristics are all improved by melanocortins, which, however, vary in potency, with α-MSH being themost effectvie. Tissue substrate, dosage, critical time periods and pattern of neuropeptide administration are all important variables. Melanocortins and protect central neurons affecting motor behavior development or following neuronal damage in the adult brain. Possible mechanisms of melanocortin action are discussed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0163-7258eISSN: 1879-016XDOI: 10.1016/0163-7258(94)90002-7Titel-ID: cdi_proquest_miscellaneous_76882834
- Format
- –
- Schlagworte
- ACTH peptides, Adrenocorticotropic Hormone - chemistry, Adrenocorticotropic Hormone - pharmacology, Adrenocorticotropic Hormone - physiology, Amino Acid Sequence, Animals, Animals, Newborn, behavior, Biological and medical sciences, Cells, Cultured, devleopment, Electrophysiology, Humans, Medical sciences, Melanocortins, Miscellaneous, Molecular Sequence Data, Motor Activity - drug effects, Muscle Development, Muscles - drug effects, Muscles - innervation, Nerve Regeneration - drug effects, Neuromuscular Agents - administration & dosage, Neuromuscular Agents - pharmacology, Neuromuscular Agents - therapeutic use, Neuromuscular Junction - drug effects, neuromuscular system, Neurons - cytology, Neurons - drug effects, Neurons - physiology, Neuropharmacology, Pharmacology. Drug treatments, Rats, Receptors, Corticotropin - drug effects, Receptors, Corticotropin - metabolism, regeneration, Structure-Activity Relationship